Drug Information
Drug General Information | Top | |||
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Drug ID |
D05VRO
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Former ID |
DIB019495
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Drug Name |
PMID9003518C4
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Synonyms |
GTPL6721
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
Structure |
Download2D MOL
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Formula |
C28H48OS
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Canonical SMILES |
CC(=CCCSCCCC(=CCCC=C(C)CCC=C(C)CCC1C(O1)(C)C)C)C
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InChI |
1S/C28H48OS/c1-23(2)13-11-21-30-22-12-18-25(4)15-9-8-14-24(3)16-10-17-26(5)19-20-27-28(6,7)29-27/h13-15,17,27H,8-12,16,18-22H2,1-7H3/b24-14?,25-15+,26-17+
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InChIKey |
SFOVLQYHQCMFTD-VLUDVKJZSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Lanosterol synthase (LSS) | Target Info | Inhibitor | [1] |
BioCyc | Cholesterol biosynthesis II (via 24,25-dihydrolanosterol) | |||
Cholesterol biosynthesis III (via desmosterol) | ||||
Cholesterol biosynthesis I | ||||
Superpathway of cholesterol biosynthesis | ||||
Lanosterol biosynthesis | ||||
KEGG Pathway | Steroid biosynthesis | |||
Metabolic pathways | ||||
Biosynthesis of antibiotics | ||||
Panther Pathway | Cholesterol biosynthesis | |||
Pathwhiz Pathway | Steroid Biosynthesis | |||
Reactome | Cholesterol biosynthesis | |||
Activation of gene expression by SREBF (SREBP) | ||||
WikiPathways | Activation of Gene Expression by SREBP (SREBF) | |||
SREBP signalling | ||||
Cholesterol Biosynthesis | ||||
Cholesterol biosynthesis |
References | Top | |||
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REF 1 | Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. J Med Chem. 1997 Jan 17;40(2):201-9. | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6721). |
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