Drug Information
Drug General Information | Top | |||
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Drug ID |
D05UQD
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Former ID |
DCL000188
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Drug Name |
Omapatrilat
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Synonyms |
BMS-186716; Omapatrilat (JAN/USAN/INN); (4S,7S,10aS)-5-oxo-4-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-2,3,4,7,8,9,10,10a-octahydropyrido[2,1-b][1,3]thiazepine-7-carboxylic acid
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Drug Type |
Small molecular drug
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Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Terminated | [1] | |
Company |
Bristol-Myers Squibb
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Structure |
Download2D MOL |
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Formula |
C19H24N2O4S2
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Canonical SMILES |
C1CC(N2C(C1)SCCC(C2=O)NC(=O)C(CC3=CC=CC=C3)S)C(=O)O
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InChI |
1S/C19H24N2O4S2/c22-17(15(26)11-12-5-2-1-3-6-12)20-13-9-10-27-16-8-4-7-14(19(24)25)21(16)18(13)23/h1-3,5-6,13-16,26H,4,7-11H2,(H,20,22)(H,24,25)/t13-,14-,15-,16-/m0/s1
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InChIKey |
LVRLSYPNFFBYCZ-VGWMRTNUSA-N
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CAS Number |
CAS 167305-00-2
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
ChEBI ID |
CHEBI:135660
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Target and Pathway | Top | |||
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Target(s) | Angiotensin-converting enzyme (ACE) | Target Info | Modulator | [1] |
Neutral endopeptidase (MME) | Target Info | Modulator | [1] | |
KEGG Pathway | Renin-angiotensin system | |||
Hematopoietic cell lineage | ||||
Protein digestion and absorption | ||||
Alzheimer's disease | ||||
Chagas disease (American trypanosomiasis) | ||||
Hypertrophic cardiomyopathy (HCM) | ||||
NetPath Pathway | EGFR1 Signaling Pathway | |||
TGF_beta_Receptor Signaling Pathway | ||||
Pathwhiz Pathway | Angiotensin Metabolism | |||
Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
WikiPathways | Metabolism of Angiotensinogen to Angiotensins | |||
Primary Focal Segmental Glomerulosclerosis FSGS | ||||
Alzheimers Disease | ||||
ACE Inhibitor Pathway |
References | Top | |||
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REF 1 | Omapatrilat, a dual angiotensin-converting enzyme and neutral endopeptidase inhibitor, prevents fatty streak deposit in apolipoprotein E-deficient mice. Atherosclerosis. 2001 Apr;155(2):291-5. |
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