Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D05RLR
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| Former ID |
DNC008846
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| Drug Name |
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole
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| Synonyms |
1-((2-Chlorophenyl)diphenylmethyl)-1H-pyrazole; TRAM-34; 289905-88-0; Tram 34; 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole; AC1LCVHZ; CHEMBL498270; CHEBI:34990; 1-[(2-chlorophenyl)-diphenylmethyl]pyrazole; 1-(2-Chlorophenyl)diphenyl)methyl]-1H-pyrazole; SureCN41130; TRAM34; SCHEMBL41130; GTPL2336; KS-00000OJW; CTK0J1643; DTXSID70349650; MolPort-003-850-592; EX-A2316; BCP01324; ZINC3975392; BDBM50279107; ANW-72309; s1160; MFCD09842562; AKOS005146304; CS-1921; ACN-048484; MP-2041; API0000868; DS-2617; NCGC00165909-03; NCGC00165909-02
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| Drug Type |
Small molecular drug
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| Indication | Conjunctival fibrosis [ICD-11: 9A61.3; ICD-10: H11.2] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C22H17ClN2
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| Canonical SMILES |
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CC=N4
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| InChI |
1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
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| InChIKey |
KBFUQFVFYYBHBT-UHFFFAOYSA-N
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| CAS Number |
CAS 289905-88-0
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:34990
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcium-activated potassium channel (KCN) | Target Info | Inhibitor | [2] |
| Calcium-activated potassium channel KCa3.1 (KCNN4) | Target Info | Blocker (channel blocker) | [3] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Blockade of KCa3.1: A novel target to treat TGF-1 induced conjunctival fibrosis.Exp Eye Res. 2018 Feb;167:140-144. | |||
| REF 2 | Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2299-304. | |||
| REF 3 | Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis. Circulation. 2003 Sep 2;108(9):1119-25. | |||
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