Drug Information
Drug General Information | Top | |||
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Drug ID |
D05RCG
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Former ID |
DNC009249
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Drug Name |
2,7-Bis[2-(piperazino)acetamido]anthraquinone
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Synonyms |
2,7-Bis[2-(piperazino)acetamido]anthraquinone; SCHEMBL4291737; CHEMBL495308
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C26H30N6O4
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Canonical SMILES |
C1CN(CCN1)CC(=O)NC2=CC3=C(C=C2)C(=O)C4=C(C3=O)C=C(C=C4)NC(=O)CN5CCNCC5
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InChI |
1S/C26H30N6O4/c33-23(15-31-9-5-27-6-10-31)29-17-1-3-19-21(13-17)26(36)22-14-18(2-4-20(22)25(19)35)30-24(34)16-32-11-7-28-8-12-32/h1-4,13-14,27-28H,5-12,15-16H2,(H,29,33)(H,30,34)
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InChIKey |
OBWFXMCXHJYGRS-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | TERT messenger RNA (TERT mRNA) | Target Info | Inhibitor | [1] |
KEGG Pathway | HTLV-I infection | |||
NetPath Pathway | IL2 Signaling Pathway | |||
Pathway Interaction Database | Validated targets of C-MYC transcriptional activation | |||
Regulation of Telomerase | ||||
IL2 signaling events mediated by PI3K | ||||
Regulation of nuclear beta catenin signaling and target gene transcription | ||||
HIF-1-alpha transcription factor network | ||||
Reactome | Formation of the beta-catenin:TCF transactivating complex | |||
WikiPathways | TGF beta Signaling Pathway | |||
miR-targeted genes in lymphocytes - TarBase | ||||
miR-targeted genes in epithelium - TarBase | ||||
Telomere Maintenance |
References | Top | |||
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REF 1 | Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. |
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