Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05OIF
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| Former ID |
DIB020519
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| Drug Name |
N-ethylhistamine
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| Synonyms |
479408-49-6; 2-(1-ethyl-1h-imidazol-4-yl)ethanamine; 1-ETHYL-1H-IMIDAZOLE-4-ETHANAMINE; 2-(1-Ethyl-1H-imidazol-4-yl)ethan-1-amine; N-ethylhistamine; 2-(1-Ethyl-1H-imidazol-4-yl)ethylamine; CHEMBL46296; SCHEMBL589342; GTPL1271; CTK4J0489; DTXSID90658170; LIXGKSRWGHVUHT-UHFFFAOYSA-N; ZINC29412524; 2-(1-ethylimidazol-4-yl)ethanamine; AKOS006337816
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C7H13N3
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| Canonical SMILES |
CCN1C=C(N=C1)CCN
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| InChI |
1S/C7H13N3/c1-2-10-5-7(3-4-8)9-6-10/h5-6H,2-4,8H2,1H3
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| InChIKey |
LIXGKSRWGHVUHT-UHFFFAOYSA-N
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| CAS Number |
CAS 479408-49-6
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H4 receptor (H4R) | Target Info | Agonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCR ligand binding | |||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1271). | |||
| REF 2 | Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br J Pharmacol. 2006 Apr;147(7):744-54. | |||
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