Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05NSP
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| Former ID |
DNC007348
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| Drug Name |
GNF-PF-4599
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| Synonyms |
GNF-PF-4599; TCMDC-125680; CHEMBL227704; MolPort-007-928-115; AKOS021616514; AKOS001585537; MCULE-4162592697; SR-01000581334; SR-01000581334-1
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C24H29F3N4O3
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| Canonical SMILES |
CC1CC(CN(C1)CCCNC2=C(C=C(C=C2)C(=O)NC3=CC=C(C=C3)C(F)(F)F)[N+](=O)[O-])C
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| InChI |
1S/C24H29F3N4O3/c1-16-12-17(2)15-30(14-16)11-3-10-28-21-9-4-18(13-22(21)31(33)34)23(32)29-20-7-5-19(6-8-20)24(25,26)27/h4-9,13,16-17,28H,3,10-12,14-15H2,1-2H3,(H,29,32)
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| InChIKey |
VWDZICDNGXUIKB-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) | Target Info | Inhibitor | [1] |
| KEGG Pathway | MAPK signaling pathway | |||
| Calcium signaling pathway | ||||
| Circadian entrainment | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | NCAM1 interactions | |||
| WikiPathways | Corticotropin-releasing hormone | |||
| NCAM signaling for neurite out-growth | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 3D pharmacophore based virtual screening of T-type calcium channel blockers. Bioorg Med Chem. 2007 Jan 15;15(2):1091-105. | |||
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