Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05KVC
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| Former ID |
DIB016461
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| Drug Name |
Paliroden
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| Synonyms |
SR-57667; SR-57667B
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| Drug Type |
Small molecular drug
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| Indication | Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Phase 2 | [1] | |
| Company |
Sanofi-aventis
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| Structure |
 |
Download2D MOL |
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| Formula |
C26H24F3N
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| Canonical SMILES |
C1CN(CC=C1C2=CC(=CC=C2)C(F)(F)F)CCC3=CC=C(C=C3)C4=CC=CC=C4
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| InChI |
1S/C26H24F3N/c27-26(28,29)25-8-4-7-24(19-25)23-14-17-30(18-15-23)16-13-20-9-11-22(12-10-20)21-5-2-1-3-6-21/h1-12,14,19H,13,15-18H2
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| InChIKey |
CNEWKIDCGDXBDE-UHFFFAOYSA-N
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| CAS Number |
CAS 188396-77-2
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutamate receptor AMPA 2 (GRIA2) | Target Info | Modulator | [2] |
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | Ionotropic glutamate receptor pathway | |||
| Metabotropic glutamate receptor group III pathway | ||||
| Pathway Interaction Database | N-cadherin signaling events | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00285025) Study of the Effect of SR57667B in Patients With Alzheimer's Disease. U.S. National Institutes of Health. | |||
| REF 2 | Mechanism of inhibition of the GluA2 AMPA receptor channel opening by talampanel and its enantiomer: the stereochemistry of the 4-methyl group on the diazepine ring of 2,3-benzodiazepine derivatives.ACS Chem Neurosci.2013 Apr 17;4(4):635-44. | |||
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