Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05JNI
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| Former ID |
DAP000838
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| Drug Name |
Framycetin
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| Synonyms |
Neomycin; neomycin; NEOMYCIN B; Soframycin; Actiline; Mycifradin; Fradiomycin; Soframycine; Framycetinum; Framycetine; Framicetina; Neomas; Fradiomycinum; Antibiotique; Nivemycin; Actilin; Neolate; Enterfram; Myacyne; Framygen; Caswell No 595; Vonamycin powder V; Neomycin B sulfate; Neomin; Neomcin; Fradiomycin B; Neo-Rx; Neomicina [DCIT]; Framycetinum [INN-Latin]; PIMAVECORT; Neobrettin; Neo-Fradin; 119-04-0; Neomycine [INN-French]; Neomycinum [INN-Latin]; Framycetine [INN-French]; Framicetina [INN-Spanish]; USAF CB-19; Endomixin; Fraquinol; Myacine; Myciguent; NMY; Neobiotic; Neomicina; Neomycinum; Tuttomycin; VONAMYCIN; NEOMYCIN AND POLYMYXIN B SULFATES; NEOMYCIN SULFATE; Neomycin solution; Soframycin Ophthalmic; Antibiotic 10676; Antibiotic produced by Streptomyces decaris Neomycin B; Framycetin (INN); Soframycin (TN); Framycetin [INN:BAN:DCF]; Sofra-Tulle (TN); BDG-(1-4)CYY-(5-1)RIB-(3-1)IDG; BDG-(1-4)NEB-(5-1)RIB-(3-1)NED; (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside; (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol; D-Streptamine, O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-O-beta-D-ribofuranosyl-(1->5)]-O-[2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1->4)]-2-deoxy
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| Drug Type |
Small molecular drug
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| Indication | Acute liver failure [ICD-11: DB91] | Approved | [1], [2] | |
| Alcoholic cirrhosis of liver [ICD-11: DB94] | Approved | [1], [2] | ||
| Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Approved | [3] | ||
| Therapeutic Class |
Antibiotics
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| Structure |
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Download2D MOL |
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| Formula |
C23H46N6O13
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| Canonical SMILES |
C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N
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| InChI |
1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
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| InChIKey |
PGBHMTALBVVCIT-VCIWKGPPSA-N
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| CAS Number |
CAS 119-04-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4872, 600744, 7886109, 7886110, 7889440, 8027095, 8155893, 11108087, 14789604, 16359677, 17398248, 24886366, 24897464, 26705169, 26713687, 26715354, 29227077, 46505525, 46508892, 47589231, 48185242, 48259497, 48416318, 48498331, 49699023, 49703385, 49997098, 49997102, 50124333, 53788467, 80496344, 85164700, 92308991, 104317690, 123097006, 124576752, 124766144, 126666617, 127317005, 127317006, 127317007, 127317008, 127317009, 127317010, 127317011, 127317012, 127317013, 127317014, 127317015, 127317016
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| ChEBI ID |
CHEBI:7508
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| ADReCS Drug ID | BADD_D00975 ; BADD_D01551 ; BADD_D01552 | |||
| SuperDrug ATC ID |
A01AB08; A07AA01; B05CA09; D06AX04; D09AA01; J01GB05; R01AX08; R02AB01; S01AA03; S01AA07; S02AA07; S03AA01
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| SuperDrug CAS ID |
cas=000119040
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial 16S ribosomal RNA (Bact 16S rRNA) | Target Info | Binder | [4] |
| Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) | Target Info | Binder | [4], [5] | |
| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 709). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 060304. | |||
| REF 3 | Drug information of Framycetin, 2008. eduDrugs. | |||
| REF 4 | Antistaphylococcal activity of gentamicin. Minerva Med. 1975 Dec 8;66(84):4505-26. | |||
| REF 5 | Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9. | |||
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