Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D05JAZ
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| Former ID |
DNC012955
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| Drug Name |
2-amino-2-(3-chloro-4-fluorophenyl)acetic acid
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| Synonyms |
261762-99-6; 2-amino-2-(3-chloro-4-fluorophenyl)acetic acid; 3-Chloro-4-fluoro-DL-phenylglycine; C8H7ClFNO2; CHEMBL203905; amino(3-chloro-4-fluorophenyl)acetic acid; AC1MCND8; SCHEMBL8196588; KS-00000ZXX; CTK8F0591; DTXSID40378674; MolPort-000-153-073; JRD-1093; SBB093187; BDBM50179692; 8653AD; 2-(3-Chloro-4-fluorophenyl)glycine; MFCD01631397; AKOS032962888; AKOS015907725; MCULE-4108995551; RTR-011871; PS-6305; SY044823; TR-011871; ST51041478; FT-0676194; MFCD01631397 (95%); C-5924
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C8H7ClFNO2
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| Canonical SMILES |
C1=CC(=C(C=C1C(C(=O)O)N)Cl)F
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| InChI |
1S/C8H7ClFNO2/c9-5-3-4(1-2-6(5)10)7(11)8(12)13/h1-3,7H,11H2,(H,12,13)
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| InChIKey |
DVSWHHQDQJPPBH-UHFFFAOYSA-N
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| CAS Number |
CAS 261762-99-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | MAPK signaling pathway | |||
| Cardiac muscle contraction | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Oxytocin signaling pathway | ||||
| Hypertrophic cardiomyopathy (HCM) | ||||
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ||||
| Dilated cardiomyopathy | ||||
| Panther Pathway | Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||
| WikiPathways | Arrhythmogenic Right Ventricular Cardiomyopathy | |||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. | |||
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