Drug Information
Drug General Information | Top | |||
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Drug ID |
D05HGU
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Former ID |
DNC012571
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Drug Name |
IQM-95333
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Synonyms |
IQM-95333; CHEMBL113718; IQM95333; AC1NSK6B; BDBM50060319; tert-butyl N-[(2S)-1-[[(4aS,5R)-2-benzyl-1,3-dioxo-4,4a,5,6,7,8-hexahydropyrido[1,2-c]pyrimidin-5-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate; [(S)-1-((4aS,5R)-2-Benzyl-1,3-dioxo-octahydro-pyrido[1,2-c]pyrimidin-5-ylcarbamoyl)-2-(1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C31H37N5O5
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Canonical SMILES |
CC(C)(C)OC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC3CCCN4C3CC(=O)N(C4=O)CC5=CC=CC=C5
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InChI |
1S/C31H37N5O5/c1-31(2,3)41-29(39)34-25(16-21-18-32-23-13-8-7-12-22(21)23)28(38)33-24-14-9-15-35-26(24)17-27(37)36(30(35)40)19-20-10-5-4-6-11-20/h4-8,10-13,18,24-26,32H,9,14-17,19H2,1-3H3,(H,33,38)(H,34,39)/t24-,25+,26+/m1/s1
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InChIKey |
JRSRZYFBWXHHNX-ZNZIZOMTSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Cholecystokinin receptor type A (CCKAR) | Target Info | Inhibitor | [1] |
Gastrin/cholecystokinin type B receptor (CCKBR) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Gastric acid secretion | ||||
Insulin secretion | ||||
Pancreatic secretion | ||||
Panther Pathway | CCKR signaling map ST | |||
Pathwhiz Pathway | Gastric Acid Production | |||
Reactome | Peptide ligand-binding receptors | |||
G alpha (q) signalling events | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Secretion of Hydrochloric Acid in Parietal Cells | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecy... J Med Chem. 1997 Oct 10;40(21):3402-7. |
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