Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05GYL
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| Former ID |
DIB012706
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| Drug Name |
UR-63325
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| Synonyms |
DP-1; Histamine H4 antagonist (allergic rhinitis, asthma), Palau
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| Indication | Allergic rhinitis [ICD-11: CA08.0] | Phase 2 | [1] | |
| Company |
Palau Pharma SA
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| Structure |
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Download2D MOL |
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| Formula |
C13H17N5O
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| Canonical SMILES |
CNC1CN(C1)C2=NC(=NC3=C2OC4=C3CCC4)N
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| InChI |
1S/C13H17N5O/c1-15-7-5-18(6-7)12-11-10(16-13(14)17-12)8-3-2-4-9(8)19-11/h7,15H,2-6H2,1H3,(H2,14,16,17)
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| InChIKey |
WUSKTVHULHXVSO-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H4 receptor (H4R) | Target Info | Antagonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCR ligand binding | |||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01260753) Proof of Activity Study of UR-63325 in Allergic Rhinitis Induced by Nasal Challenge. U.S. National Institutes of Health. | |||
| REF 2 | Azines as histamine H4 receptor antagonists. Front Biosci (Schol Ed). 2012 Jan 1;4:967-87. | |||
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