Drug Information
Drug General Information | Top | |||
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Drug ID |
D05FFY
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Former ID |
DNC004483
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Drug Name |
1-(4-Cyanobenzyl)-5-methyl-1H-imidazole
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Synonyms |
4-(5-Methyl-imidazol-1-ylmethyl)-benzonitrile
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C12H11N3
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Canonical SMILES |
CC1=CN=CN1CC2=CC=C(C=C2)C#N
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InChI |
1S/C12H11N3/c1-10-7-14-9-15(10)8-12-4-2-11(6-13)3-5-12/h2-5,7,9H,8H2,1H3
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InChIKey |
JYTDMONWVZXEMX-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Aromatase (CYP19A1) | Target Info | Inhibitor | [2] |
Steroid 11-beta-hydroxylase (CYP11B1) | Target Info | Inhibitor | [1] | |
BioCyc | Superpathway of steroid hormone biosynthesis | |||
Glucocorticoid biosynthesis | ||||
Mineralocorticoid biosynthesis | ||||
Estradiol biosynthesis II | ||||
Estradiol biosynthesis I | ||||
KEGG Pathway | Steroid hormone biosynthesis | |||
Metabolic pathways | ||||
Ovarian steroidogenesis | ||||
NetPath Pathway | FSH Signaling Pathway | |||
Panther Pathway | Androgen/estrogene/progesterone biosynthesis | |||
Pathwhiz Pathway | Steroidogenesis | |||
Androgen and Estrogen Metabolism | ||||
Reactome | Glucocorticoid biosynthesis | |||
Endogenous sterols | ||||
WikiPathways | Metapathway biotransformation | |||
Oxidation by Cytochrome P450 | ||||
Metabolism of steroid hormones and vitamin D | ||||
Corticotropin-releasing hormone | ||||
Tryptophan metabolism | ||||
Ovarian Infertility Genes | ||||
FSH signaling pathway | ||||
Integrated Breast Cancer Pathway | ||||
Phase 1 - Functionalization of compounds |
References | Top | |||
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REF 1 | Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. | |||
REF 2 | Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J Med Chem. 1991 Feb;34(2):725-36. |
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