Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05ERT
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| Former ID |
DIB004727
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| Drug Name |
GV-196771
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| Synonyms |
GR-196771; GV-196771A
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| Drug Type |
Small molecular drug
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| Indication | Migraine [ICD-11: 8A80; ICD-10: G43, G43.9; ICD-9: 346] | Discontinued in Phase 2 | [1], [2] | |
| Company |
Glaxo Wellcome plc
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H14Cl2N2O3
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| Canonical SMILES |
C1CN(C(=O)C1=CC2=C(NC3=C2C(=CC(=C3)Cl)Cl)C(=O)O)C4=CC=CC=C4
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| InChI |
1S/C20H14Cl2N2O3/c21-12-9-15(22)17-14(18(20(26)27)23-16(17)10-12)8-11-6-7-24(19(11)25)13-4-2-1-3-5-13/h1-5,8-10,23H,6-7H2,(H,26,27)/b11-8+
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| InChIKey |
VDIRQCDDCGAGET-DHZHZOJOSA-N
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| CAS Number |
CAS 166974-22-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glycine receptor (GlyR) | Target Info | Modulator | [3] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Ligand-gated ion channel transport | |||
| WikiPathways | Iron uptake and transport | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4208). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008901) | |||
| REF 3 | First time in human for GV196771: interspecies scaling applied on dose selection. J Clin Pharmacol. 1999 Jun;39(6):560-6. | |||
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