Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05EON
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| Drug Name |
Quinolinyl compound 2
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| Synonyms |
PMID25828189-Compound-24
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| Drug Type |
Small molecular drug
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| Company |
PFIZER INC. DIDIUK, Mary FILIPSKI, Kevin J. GUZMAN-PEREZ, Angel LEE, Esther C. PFEFFERKORN, Jeffrey A. STEVENS, Benjamin TU, Meihua
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H27N3O3
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| Canonical SMILES |
CCCC(C1=CC=C(C=C1)C(=O)NCCC(=O)O)NC2=NC3=CC=CC=C3C=C2C
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| InChI |
1S/C24H27N3O3/c1-3-6-20(26-23-16(2)15-19-7-4-5-8-21(19)27-23)17-9-11-18(12-10-17)24(30)25-14-13-22(28)29/h4-5,7-12,15,20H,3,6,13-14H2,1-2H3,(H,25,30)(H,26,27)(H,28,29)
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| InChIKey |
KQBQZWBDDOVGRD-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Antagonist | [1] |
| Target's Patent Info | Glucagon receptor (GCGR) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon signaling in metabolic regulation | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. | |||
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