Drug Information
Drug General Information | Top | |||
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Drug ID |
D05DON
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Former ID |
DIB004320
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Drug Name |
MILACAINIDE TARTRATE
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Synonyms |
(R)-RO-22-9194.tartrate; 2(R)-Amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide D-tartrate
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Indication | Cardiac arrhythmias [ICD-11: BC9Z; ICD-9: 427] | Discontinued in Phase 2 | [1] | |
Structure |
Download2D MOL
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Formula |
C23H31N3O7
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Canonical SMILES |
CC1=C(C(=CC=C1)C)N(CCCC2=CN=CC=C2)C(=O)C(C)N.C(C(C(=O)O)O)(C(=O)O)O
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InChI |
1S/C19H25N3O.C4H6O6/c1-14-7-4-8-15(2)18(14)22(19(23)16(3)20)12-6-10-17-9-5-11-21-13-17;5-1(3(7)8)2(6)4(9)10/h4-5,7-9,11,13,16H,6,10,12,20H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t16-;1-,2-/m10/s1
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InChIKey |
UKFWRCBTXJZERY-ZKBHHEPKSA-N
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CAS Number |
CAS 141725-10-2
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Thromboxane-A synthase (TBXAS1) | Target Info | Antagonist | [2] |
BioCyc | C20 prostanoid biosynthesis | |||
KEGG Pathway | Arachidonic acid metabolism | |||
Metabolic pathways | ||||
Platelet activation | ||||
Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
WikiPathways | Prostaglandin Synthesis and Regulation | |||
Arachidonic acid metabolism | ||||
Phase 1 - Functionalization of compounds | ||||
Eicosanoid Synthesis |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001597) | |||
REF 2 | Effects of the new class I antiarrhythmic agent Ro 22-9194, (2R)-2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide D-tartrate, on ischemia- and reperfusion-induced arrhythmias in dogs: involvement of thromboxane A2 synthase inhibitory activity. J Pharmacol Exp Ther. 1996 Nov;279(2):877-83. |
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