Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D05CPV
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| Former ID |
DCL000783
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| Drug Name |
Dronedarone
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| Synonyms |
Multaq; Dronedarone [INN]; SR 33589; SR 33589B; Dronedarone (INN); Sanofi-Aventis brand of dronedarone; N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide; N-(2-Butyl-3-(p-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide; N-[2-butyl-3-{4-[3-(dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide; N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-methanesulfonamide
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| Drug Type |
Small molecular drug
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| Indication | Angina pectoris [ICD-11: BA40; ICD-9: 413] | Approved | [1], [2] | |
| Atrial fibrillation [ICD-11: BC81.3; ICD-10: I48] | Withdrawn from market | [1], [3] | ||
| Company |
Sanofi-Synthelabo
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| Structure |
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Download2D MOL |
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| Formula |
C31H44N2O5S
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| Canonical SMILES |
CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC
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| InChI |
1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3/h13-18,23,32H,5-12,19-22H2,1-4H3
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| InChIKey |
ZQTNQVWKHCQYLQ-UHFFFAOYSA-N
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| CAS Number |
CAS 141626-36-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9368719, 14861729, 17396708, 30413541, 49991104, 50605127, 53801270, 57399553, 85210065, 87350388, 92721602, 99246129, 103450658, 104040015, 109692880, 113442043, 123121569, 124899317, 125340836, 126619012, 126666952, 129941685, 131298725, 134339267, 134358403, 135184552, 137138586, 139991786, 144206559, 152258951, 160647796, 162011679, 162190611, 164825705, 165702342, 170465064, 174527431, 175268727, 175426865, 179322835, 184547228, 185974016, 187051768, 198991949, 223392235, 223659005, 224585881, 226483798, 251893827
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| ChEBI ID |
CHEBI:50659
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| ADReCS Drug ID | BADD_D00730 | |||
| SuperDrug ATC ID |
C01BD07
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Potassium channel unspecific (KC) | Target Info | Inhibitor | [4] |
| Voltage-gated potassium channel Kv1.5 (KCNA5) | Target Info | Blocker | [3] | |
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Voltage gated Potassium channels | |||
| WikiPathways | Potassium Channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7465). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22. | |||
| REF 4 | Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. | |||
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