Drug Information
Drug General Information | Top | |||
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Drug ID |
D05COE
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Drug Name |
PMID30107136-Compound-Example52
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Drug Type |
Small molecule immunotherapy
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Indication | Hepatitis [ICD-11: DB97.Z] | Patented | [1] | |
Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 42] | Patented | [1] | ||
Infectious disease [ICD-11: 1A00-CA43.1; ICD-10: A00-B99; ICD-9: 001-139] | Patented | [1] | ||
Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Patented | [1] | ||
Company |
Incyte Corporation
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Structure |
Download2D MOL |
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Formula |
C22H18N6OS
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Canonical SMILES |
CN1C2=CC=CC(=C2C=N1)C3=C(C(=CC=C3)NC(=O)C4=NC5=C(S4)CNCC5)C#N
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InChI |
1S/C22H18N6OS/c1-28-19-7-3-5-14(16(19)11-25-28)13-4-2-6-17(15(13)10-23)26-21(29)22-27-18-8-9-24-12-20(18)30-22/h2-7,11,24H,8-9,12H2,1H3,(H,26,29)
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InChIKey |
UPRJKKJMZSATGW-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) | Target Info | Inhibitor | [1] |
Target's Patent Info | PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) | Target's Patent Info | [1] |
References | Top | |||
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REF 1 | A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. |
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