Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04XVU
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| Former ID |
DIB002119
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| Drug Name |
GKT-137831
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| Synonyms |
GKT-01; NADPH oxidase inhibitor (oral, renal cancer/ idiopathic pulmonary fibrosis), GenKyoTex
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| Drug Type |
Small molecular drug
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| Indication | Fibrosis [ICD-11: GA14-GC01; ICD-10: L90.5; ICD-9: 709.2] | Phase 2 | [1] | |
| Company |
Genkyotex innovation
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| Structure |
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Download2D MOL |
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| Formula |
C21H19ClN4O2
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| Canonical SMILES |
CN1C(=O)C=C2C(=C1C3=CC(=CC=C3)N(C)C)C(=O)N(N2)C4=CC=CC=C4Cl
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| InChI |
1S/C21H19ClN4O2/c1-24(2)14-8-6-7-13(11-14)20-19-16(12-18(27)25(20)3)23-26(21(19)28)17-10-5-4-9-15(17)22/h4-12,23H,1-3H3
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| InChIKey |
RGYQPQARIQKJKH-UHFFFAOYSA-N
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| CAS Number |
CAS 1218942-37-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | NADPH oxidase (NOX) | Target Info | Modulator | [2] |
| NADPH oxidase 4 (NOX4) | Target Info | Modulator | [2] | |
| KEGG Pathway | HIF-1 signaling pathway | |||
| Phagosome | ||||
| Osteoclast differentiation | ||||
| Leukocyte transendothelial migration | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| TSH Signaling Pathway | ||||
| Pathwhiz Pathway | Thyroid hormone synthesis | |||
| Pathway Interaction Database | Signaling events mediated by PTP1B | |||
| RAC1 signaling pathway | ||||
| WikiPathways | Oxidative Stress | |||
| Spinal Cord Injury | ||||
| Vitamin D Receptor Pathway | ||||
| TNF alpha Signaling Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT02010242) Safety and Efficacy of Oral GKT137831 in Patient With Type 2 Diabetes and Albuminuria. U.S. National Institutes of Health. | |||
| REF 2 | Nicotinamide Adenine Dinucleotide Phosphate Oxidase (NOX) in Experimental Liver Fibrosis: GKT137831 as a Novel Potential Therapeutic Agent. Hepatology. 2012 December; 56(6): 2316-2327. | |||
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