Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04WYX
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| Drug Name |
Netarsudil
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| Synonyms |
UNII-W6I5QDT7QI; W6I5QDT7QI; Netarsudil mesylate; Netarsudil [USAN]; AR-11324 free base; Netarsudil [USAN:INN]; Netarsudil (USAN/INN); GTPL9322; SCHEMBL16036278; ZINC113149554; AR11324; AR-11324; ester 60; 1628418-15-4
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| Indication | Open-angle glaucoma [ICD-11: 9C61] | Approved | [1] | |
| Glaucoma/ocular hypertension [ICD-11: 9C61; ICD-9: 365] | Phase 2 | [2] | ||
| Company |
Aerie Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C28H27N3O3
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| Canonical SMILES |
CC1=CC(=C(C=C1)C(=O)OCC2=CC=C(C=C2)C(CN)C(=O)NC3=CC4=C(C=C3)C=NC=C4)C
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| InChI |
1S/C28H27N3O3/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32)/t26-/m1/s1
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| InChIKey |
OURRXQUGYQRVML-AREMUKBSSA-N
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| CAS Number |
CAS 1254032-66-0
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| PubChem Compound ID | ||||
| ADReCS Drug ID | BADD_D02519 | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. | |||
| REF 2 | Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24(1):51-4. | |||
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