Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04UKC
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| Former ID |
DNCL001915
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| Drug Name |
Riociguat
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| Synonyms |
Riociguat; 625115-55-1; Adempas; Riociguat (BAY 63-2521); BAY 63-2521; riociguatum; UNII-RU3FE2Y4XI; RU3FE2Y4XI; CHEBI:76018; Methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate; Methyl N-(4,6-diamino-2-{1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate; N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester
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| Drug Type |
Small molecular drug
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| Indication | Pulmonary arterial hypertension [ICD-11: BB01.0; ICD-9: 416] | Approved | [1], [2] | |
| Company |
Bayer HealthCare Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H19FN8O2
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| Canonical SMILES |
CN(C1=C(N=C(N=C1N)C2=NN(C3=C2C=CC=N3)CC4=CC=CC=C4F)N)C(=O)OC
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| InChI |
1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)
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| InChIKey |
WXXSNCNJFUAIDG-UHFFFAOYSA-N
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| CAS Number |
CAS 625115-55-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16393220, 23472114, 42384129, 80225677, 87550988, 124490312, 124759703, 126644888, 126680174, 135263495, 136946407, 137126926, 139526076, 144115685, 152040137, 152255058, 152258603, 160647437, 160682218, 164042214, 164347391, 170501515, 172919534, 178101941, 185997052, 198980755, 198993771, 211536089, 223399697, 223676750, 224002579, 226595445, 242826663, 249737057, 249821754, 251971381, 252155071, 252211224, 252216203, 252316121, 252438349, 252553251
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| ChEBI ID |
CHEBI:76018
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| ADReCS Drug ID | BADD_D01948 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Soluble guanylyl cyclase (GUCY2D) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5257). | |||
| REF 2 | Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. | |||
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