Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04TLJ
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| Former ID |
DIB010149
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| Drug Name |
Soblidotin
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| Synonyms |
Auristatin PE; Dolastatin derivative; TZT-1027; YHI-501; ZT-1027
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 2 | [1] | |
| Company |
Teikoku Hormone Manufacturing Co Ltd
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| Structure |
 |
Download2D MOL
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| Formula |
C39H67N5O6
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| Canonical SMILES |
CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NCCC2=CC=CC=C2)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)N(C)C
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| InChI |
1S/C39H67N5O6/c1-13-27(6)35(43(10)39(48)33(25(2)3)41-38(47)34(26(4)5)42(8)9)31(49-11)24-32(45)44-23-17-20-30(44)36(50-12)28(7)37(46)40-22-21-29-18-15-14-16-19-29/h14-16,18-19,25-28,30-31,33-36H,13,17,20-24H2,1-12H3,(H,40,46)(H,41,47)/t27-,28+,30-,31+,33-,34-,35-,36+/m0/s1
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| InChIKey |
DZMVCVHATYROOS-ZBFGKEHZSA-N
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| CAS Number |
CAS 149606-27-9
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:32135
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tubulin (TUB) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00064220) Soblidotin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma. U.S. National Institutes of Health. | |||
| REF 2 | Antitumor activity of TZT-1027 (Soblidotin). Anticancer Res. 2006 May-Jun;26(3A):1973-81. | |||
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