Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04SHK
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| Drug Name |
Isothiazolidine derivative 1
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| Synonyms |
PMID27724045-Compound-2
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| Drug Type |
Small molecular drug
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| Company |
GLAXO GROUP LIMITED DEAN, David, Kenneth WALTER, Daryl, Simon
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| Structure |
 |
Download2D MOL |
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| Formula |
C13H15ClF3N3O3S
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| Canonical SMILES |
CN1CC(N(S1(=O)=O)C)C(=O)NCC2=C(C(=CC=C2)C(F)(F)F)Cl
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| InChI |
1S/C13H15ClF3N3O3S/c1-19-7-10(20(2)24(19,22)23)12(21)18-6-8-4-3-5-9(11(8)14)13(15,16)17/h3-5,10H,6-7H2,1-2H3,(H,18,21)
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| InChIKey |
FDFVMILOAWFGGO-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | P2X purinoceptor 7 (P2RX7) | Target Info | Antagonist | [1] |
| Target's Patent Info | P2X purinoceptor 7 (P2RX7) | Target's Patent Info | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Reactome | The NLRP3 inflammasome | |||
| WikiPathways | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. | |||
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