Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04PMM
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| Former ID |
DCL000455
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| Drug Name |
AZD1386
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| Synonyms |
azd1386; 946080-23-5; AZD-1386; KB-270807; AZD 1386; SCHEMBL4257077; GTPL7820; CHEMBL3545039; AZ12457709
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| Drug Type |
Small molecular drug
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| Indication | Esophagus sensitivity [ICD-11: DA2Y-DA2Z] | Discontinued in Phase 2 | [1], [2] | |
| Gastroesophageal reflux disease [ICD-11: DA22.Z] | Discontinued in Phase 2 | [1], [2] | ||
| Therapeutic Class |
Analgesics
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| Company |
AstraZeneca
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| Structure |
 |
Download2D MOL
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| Formula |
C19H13ClF3N3O3
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| Canonical SMILES |
CC1=CC(=CC2=C1N(C(=O)C23C(=O)NC(=O)N3)CC4=CC(=CC=C4)C(F)(F)F)Cl
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| InChI |
1S/C19H13ClF3N3O3/c1-9-5-12(20)7-13-14(9)26(16(28)18(13)15(27)24-17(29)25-18)8-10-3-2-4-11(6-10)19(21,22)23/h2-7H,8H2,1H3,(H2,24,25,27,29)
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| InChIKey |
DXDVSYALLVVBOV-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Blocker | [3] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7820). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027672) | |||
| REF 3 | Clinical pipeline report, company report or official report of AstraZeneca (2009). | |||
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