Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04OMR
|
|||
| Former ID |
DNCL001630
|
|||
| Drug Name |
PF-04840082
|
|||
| Indication | Osteoporosis [ICD-11: FB83.0; ICD-10: M85.8] | Phase 1 | [1] | |
| Company |
Pfizer New York, NY
|
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dickkopf-related protein 1 (DKK1) | Target Info | Modulator | [2] |
| KEGG Pathway | Wnt signaling pathway | |||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Wnt Signaling Pathway | ||||
| FSH Signaling Pathway | ||||
| Pathway Interaction Database | Presenilin action in Notch and Wnt signaling | |||
| Wnt signaling network | ||||
| Direct p53 effectors | ||||
| Regulation of nuclear beta catenin signaling and target gene transcription | ||||
| Validated targets of C-MYC transcriptional repression | ||||
| Reactome | TCF dependent signaling in response to WNT | |||
| Negative regulation of TCF-dependent signaling by WNT ligand antagonists | ||||
| WikiPathways | Mesodermal Commitment Pathway | |||
| Endoderm Differentiation | ||||
| Differentiation Pathway | ||||
| Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
| Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| Cardiac Progenitor Differentiation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01293487) Safety And Tolerability Study Of RN564 In Women With Osteopenia And Healthy Men.. U.S. National Institutes of Health. | |||
| REF 2 | The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis. J Pharmacol Exp Ther. 2010 Apr;333(1):2-13. | |||
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