Drug Information
Drug General Information | Top | |||
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Drug ID |
D04LRQ
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Former ID |
DIB006057
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Drug Name |
TDI-0059
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Indication | Motor neurone disease [ICD-11: 8B60; ICD-10: G12.2; ICD-9: 335.2] | Investigative | [1] | |
Company |
ALS Therapy Development Foundation Inc
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Target and Pathway | Top | |||
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Target(s) | Low-affinity nerve growth factor receptor (NGFR) | Target Info | Modulator | [1] |
KEGG Pathway | Ras signaling pathway | |||
Rap1 signaling pathway | ||||
Cytokine-cytokine receptor interaction | ||||
PI3K-Akt signaling pathway | ||||
Neurotrophin signaling pathway | ||||
Transcriptional misregulation in cancer | ||||
Pathway Interaction Database | p75(NTR)-mediated signaling | |||
Neurotrophic factor-mediated Trk receptor signaling | ||||
Reactome | Axonal growth inhibition (RHOA activation) | |||
NRAGE signals death through JNK | ||||
p75NTR negatively regulates cell cycle via SC1 | ||||
Regulated proteolysis of p75NTR | ||||
NADE modulates death signalling | ||||
NRIF signals cell death from the nucleus | ||||
p75NTR recruits signalling complexes | ||||
NF-kB is activated and signals survival | ||||
Axonal growth stimulation | ||||
WikiPathways | Spinal Cord Injury | |||
BDNF signaling pathway | ||||
Signalling by NGF |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1888). |
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