Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04KWH
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| Former ID |
DNC000535
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| Drug Name |
Des-Arg(9)-[Leu(8)]-BK
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| Synonyms |
5-Chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-trichlorophenyl)aminopyridine; NBI 27914; NBI27914; NBI-27914; CHEMBL45281; SR-01000075865; Tocris-1591; Lopac-N-3911; AC1L41YH; Lopac0_000493; MLS000860080; cid_176157; GTPL3512; SCHEMBL16606734; CHEBI:93069; DTXSID20171549; HMS3261D07; HMS3371C20; HMS2230I15; ZINC2511843; Tox21_500493; BDBM50054245; CCG-204584; API0008466; LP00493; 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine; NCGC00261178-01; NCGC00015737-05
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| Drug Type |
Small molecular drug
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| Indication | Depression [ICD-11: 6A70-6A7Z; ICD-9: 311] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H20Cl4N4
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| Canonical SMILES |
CCCN(CC1CC1)C2=NC(=NC(=C2Cl)NC3=C(C=C(C=C3Cl)Cl)Cl)C
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| InChI |
1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
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| InChIKey |
KNADXBVKFAUMCR-UHFFFAOYSA-N
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| CAS Number |
CAS 184241-44-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5916225, 7980096, 10258352, 11111536, 11114145, 14930153, 17405056, 24278425, 33499833, 46500411, 47276706, 50069830, 50104903, 50104904, 53777599, 53788663, 53801052, 57395288, 80947329, 85231154, 85788155, 90340601, 92304048, 103225612, 103950895, 104425366, 121361191, 124749758, 124799473, 124880882, 124880883, 134339939, 134340268, 135154099, 135298261, 162248258, 163564447, 178126277, 179235782
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| ChEBI ID |
CHEBI:93069
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3512). | |||
| REF 2 | Evidence for the participation of kinins in Freund's adjuvant-induced inflammatory and nociceptive responses in kinin B1 and B2 receptor knockout mice. Neuropharmacology. 2001 Dec;41(8):1006-12. | |||
| REF 3 | A review of drug options in age-related macular degeneration therapy and potential new agents. Expert Opin Pharmacother. 2006 Dec;7(17):2355-68. | |||
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