Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04KMO
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| Former ID |
DNC014591
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| Drug Name |
CGP-35348
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| Synonyms |
Cgp 35348; Cgp-35348; 123690-79-9; UNII-87TI61875H; P-(3-Aminopropyl)-P-diethoxymethylphosphinic acid; CHEMBL40157; 3-aminopropyl(diethoxymethyl)phosphinic acid; Phosphinic acid, (3-aminopropyl)(diethoxymethyl)-; CGP35348; 87TI61875H; (S)-(3-Aminopropyl)(Diethoxymethyl)phosphinic Acid; CGP 35348 hydrate; (3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate; Tocris-1245; Biomol-NT_000237; AC1L32KY; C8H20NO4P; SCHEMBL195698; GTPL1069; BPBio1_000508; DTXSID70154064; QIIVUOWTHWIXFO-UHFFFAOYSA-N; MolPort-003-983-819; PDSP2_000408
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| Drug Type |
Small molecular drug
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| Indication | Epilepsy [ICD-11: 8A60-8A68] | Terminated | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H20NO4P
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| Canonical SMILES |
CCOC(OCC)P(=O)(CCCN)O
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| InChI |
1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)
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| InChIKey |
QIIVUOWTHWIXFO-UHFFFAOYSA-N
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| CAS Number |
CAS 123690-79-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6333692, 7978904, 10234391, 11113992, 14773680, 26752133, 44436671, 47285819, 47359849, 47510006, 48329015, 50064283, 57338192, 78902445, 85209006, 91746556, 92729825, 103215668, 103941375, 104379519, 126431485, 129027217, 134351796, 135065084, 135650067, 137127980, 143479288, 162220812, 170475223, 170485731, 198960763, 224931319, 226554287, 241182267, 241375318
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gamma-aminobutyric acid B receptor (GABBR) | Target Info | Modulator | [3], [4] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| GABAergic synapse | ||||
| Estrogen signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | Activation of G protein gated Potassium channels | |||
| G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Potassium Channels | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1069). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002440) | |||
| REF 3 | The selective GABAB antagonist CGP-35348 blocks spike-wave bursts in the cholesterol synthesis rat absence epilepsy model. Brain Res. 1996 Aug 12;729(2):147-50. | |||
| REF 4 | The GABAB-receptor antagonist, CGP 35348, antagonises gamma-hydroxybutyrate- and baclofen-induced alterations in locomotor activity and forebrain d... J Neural Transm (Vienna). 1996;103(11):1255-63. | |||
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