Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04IUB
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| Former ID |
DIB007247
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| Drug Name |
NT0202
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| Synonyms |
Amphetamine polistirex
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| Indication | Attention deficit hyperactivity disorder [ICD-11: 6A05.Z; ICD-9: 314] | Phase 3 | [1], [2], [3], [4], [5] | |
| Company |
Neos therapeutics
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Trace amine-associated receptor-1 (TAAR1) | Target Info | Agonist | [1], [2], [3], [4], [5] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | G alpha (s) signalling events | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology. 2014 Oct;85:499-507. | |||
| REF 2 | Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity. J Neurochem. 2003 Jul;86(2):413-21. | |||
| REF 3 | Involvement of the alpha(1D)-adrenergic receptor in methamphetamine-induced hyperthermia and neurotoxicity in rats. Neurotox Res. 2013 Aug;24(2):130-8. | |||
| REF 4 | Methamphetamine increases the hippocampal alpha(2A)-adrenergic receptor and Galpha(o) in mice. Neurosci Lett. 2002 Dec 16;334(3):145-8. | |||
| REF 5 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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