Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04HQT
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| Former ID |
DIB020758
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| Drug Name |
proglumide
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| Synonyms |
Milid; Nulsa; W-5219
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Influenza virus infection [ICD-11: 1E30-1E32] | Phase 2 | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C18H26N2O4
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| Canonical SMILES |
CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)C1=CC=CC=C1
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| InChI |
1S/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22)
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| InChIKey |
DGMKFQYCZXERLX-UHFFFAOYSA-N
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| CAS Number |
CAS 6620-60-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5236624, 7848880, 8149717, 8153032, 10321573, 11335859, 11361098, 11364226, 11366788, 11369350, 11372506, 11373889, 11377512, 11462070, 11466268, 11467388, 11485188, 11485976, 11489222, 11491259, 11492240, 11495146, 14777663, 17405393, 26612175, 26680275, 26747589, 26747590, 29224000, 47515325, 47662292, 47810761, 47810762, 47810763, 47885426, 48110460, 48185002, 48416475, 49698766, 49834543, 49972990, 50106676, 50106677, 50226741, 53777938, 56463359, 57288819, 57322526, 85088918, 85231119
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| ChEBI ID |
CHEBI:32058
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cholecystokinin receptor type A (CCKAR) | Target Info | Antagonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Insulin secretion | ||||
| Pancreatic secretion | ||||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists. Arzneimittelforschung. 1987 Nov;37(11):1265-8. | |||
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