Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04FYZ
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| Former ID |
DCL000289
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| Drug Name |
Plevitrexed (R)-isomer
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| Synonyms |
YW3548
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| Drug Type |
Small molecular drug
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| Indication | Gastric adenocarcinoma [ICD-11: 2B72; ICD-9: 151] | Phase 2 | [1] | |
| Company |
BTG
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
CC1=CC2=C(C=C1CN(CC#C)C3=CC(=C(C=C3)C(=O)NC(CCC4=NNN=N4)C(=O)O)F)C(=O)N=C(N2)C
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| PubChem Compound ID | ||||
| PubChem Substance ID |
525044, 11438742, 14763215, 14763216, 14934453, 30417265, 50068467, 57399646, 76715527, 78907166, 103066645, 103080055, 103356879, 103981287, 113453116, 117622467, 128155971, 134338945, 134338991, 134340694, 134340698, 135187320, 137542816, 138647661, 162802588, 164232738, 164764471, 180371003, 198971042, 198979701, 224042541, 226538633, 235406768, 252166490
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of plevitrexed. | |||
| REF 2 | Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors. Biochemistry. 2007 Mar 13;46(10):2823-30. | |||
| REF 3 | Differential effect of 1,10-phenanthroline on mammalian, yeast, and parasite glycosylphosphatidylinositol anchor synthesis. Biochem Biophys Res Commun. 2001 Nov 16;288(5):1112-8. | |||
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