Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04FMB
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| Former ID |
DIB010910
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| Drug Name |
XK-469
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| Synonyms |
Rac-2-[4-(7-Chloroquinoxalin-2-yloxy)phenoxy]propionic acid sodium salt
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H12ClN2NaO4
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| Canonical SMILES |
CC(C(=O)[O-])OC1=CC=C(C=C1)OC2=CN=C3C=CC(=CC3=N2)Cl.[Na+]
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| InChI |
1S/C17H13ClN2O4.Na/c1-10(17(21)22)23-12-3-5-13(6-4-12)24-16-9-19-14-7-2-11(18)8-15(14)20-16;/h2-10H,1H3,(H,21,22);/q;+1/p-1
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| InChIKey |
OJENKXNXJPNEPU-UHFFFAOYSA-M
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| CAS Number |
CAS 157434-99-6
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase II beta (TOP2B) | Target Info | Modulator | [2] |
| Panther Pathway | DNA replication | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00028522) R(+)XK469 in Treating Patients With Advanced Neuroblastoma. U.S. National Institutes of Health. | |||
| REF 2 | A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469.Pharmacogenet Genomics.2014 Feb;24(2):129-32. | |||
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