Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04FFY
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| Former ID |
DCL000046
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| Drug Name |
AMG-8563
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| Synonyms |
SCHEMBL15446081
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD-11: MG30-MG3Z] | Investigative | [1] | |
| Therapeutic Class |
Analgesics
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| Company |
Amgen
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H25F3N2O2
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| Canonical SMILES |
C1CCN(CC1)C2=C(C=CC(=C2)C(F)(F)F)C=CC(=O)NC3=CC=CC4=C3CC(C4)O
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| InChI |
1S/C24H25F3N2O2/c25-24(26,27)18-9-7-16(22(14-18)29-11-2-1-3-12-29)8-10-23(31)28-21-6-4-5-17-13-19(30)15-20(17)21/h4-10,14,19,30H,1-3,11-13,15H2,(H,28,31)/b10-8+/t19-/m0/s1
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| InChIKey |
HAZYXDWNLMGLIS-RQMBKDMJSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Blocker | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Altered pharmacology of native rodent spinal cord TRPV1 after phosphorylation. Br J Pharmacol. 2013 Feb;168(4):1015-29. | |||
| REF 2 | Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. | |||
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