Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04AEG
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| Former ID |
DNC007798
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| Drug Name |
3-(2-phenylthiazol-4-yl)quinolin-2(1H)-one
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| Synonyms |
SCHEMBL5463666; CHEMBL240264; BDBM20859; quinolin-2(1H)-one derivative, 17a
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H12N2OS
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| Canonical SMILES |
C1=CC=C(C=C1)C2=NC(=CS2)C3=CC4=CC=CC=C4NC3=O
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| InChI |
1S/C18H12N2OS/c21-17-14(10-13-8-4-5-9-15(13)19-17)16-11-22-18(20-16)12-6-2-1-3-7-12/h1-11H,(H,19,21)
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| InChIKey |
OANBFUCSFFQVAU-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cyclin-dependent kinase 5 (CDK5) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Axon guidance | |||
| Alzheimer's disease | ||||
| Cocaine addiction | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Panther Pathway | Axon guidance mediated by semaphorins | |||
| Pathway Interaction Database | Reelin signaling pathway | |||
| Glucocorticoid receptor regulatory network | ||||
| Lissencephaly gene (LIS1) in neuronal migration and development | ||||
| EPHA forward signaling | ||||
| Trk receptor signaling mediated by the MAPK pathway | ||||
| Reactome | DARPP-32 events | |||
| CRMPs in Sema3A signaling | ||||
| Factors involved in megakaryocyte development and platelet production | ||||
| WikiPathways | DNA Damage Response | |||
| BDNF signaling pathway | ||||
| Alzheimers Disease | ||||
| Opioid Signalling | ||||
| Semaphorin interactions | ||||
| Factors involved in megakaryocyte development and platelet production | ||||
| Nicotine Activity on Dopaminergic Neurons | ||||
| miRNA Regulation of DNA Damage Response | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5384-9. | |||
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