Drug Information
Drug General Information | Top | |||
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Drug ID |
D03ZWB
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Former ID |
DIB018808
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Drug Name |
alpha3IA
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Synonyms |
CHEMBL413325; alpha3IA; GTPL4094; BDBM50112236; 3-(4-Methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-[2,4'']bipyridinyl-5-carboxylic acid methyl ester; methyl 5-(4-methoxyphenyl)-1-methyl-2-oxo-6-(pyridin-4-yl)-1,2-dihydropyridine-3-carboxylate
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C20H18N2O4
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Canonical SMILES |
CN1C(=C(C=C(C1=O)C(=O)OC)C2=CC=C(C=C2)OC)C3=CC=NC=C3
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InChI |
1S/C20H18N2O4/c1-22-18(14-8-10-21-11-9-14)16(12-17(19(22)23)20(24)26-3)13-4-6-15(25-2)7-5-13/h4-12H,1-3H3
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InChIKey |
LENMNEQXCQXJHV-UHFFFAOYSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | GABA(A) receptor alpha-2 (GABRA2) | Target Info | Modulator (allosteric modulator) | [2] |
GABA(A) receptor alpha-3 (GABRA3) | Target Info | Modulator (allosteric modulator) | [3] | |
GABA(A) receptor alpha-5 (GABRA5) | Target Info | Modulator (allosteric modulator) | [4] | |
GABA(A) receptor gamma-3 (GABRG3) | Target Info | Modulator (allosteric modulator) | [5] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Retrograde endocannabinoid signaling | ||||
GABAergic synapse | ||||
Morphine addiction | ||||
Nicotine addiction | ||||
Reactome | Ligand-gated ion channel transport | |||
GABA A receptor activation | ||||
WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
Iron uptake and transport | ||||
SIDS Susceptibility Pathways |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4094). | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). | |||
REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). | |||
REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). | |||
REF 5 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). |
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