Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03ZBN
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| Former ID |
DNC001058
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| Drug Name |
Olprinone
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| Synonyms |
Olprinone; 106730-54-5; loprinone; Coretec; Olprinone [INN]; UNII-4Y8BMI9YGC; 4Y8BMI9YGC; C14H10N4O; Olprinone (INN); 5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1H-pyridine-3-carbonitrile; 1,2-Dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile; 1,2-dihydro-6-methyl-2-oxo-5-(imidazo[1,2-a]pyridin-6-yl)-3-pyridinecarbonitrile; AC1L1IIG; AC1Q4Q1U; SCHEMBL27661; DTXSID1048461; CHEMBL1474900; KS-00000EYK; MolPort-006-394-808; JPAWFIIYTJQOKW-UHFFFAOYSA-N; CHEBI:135019; BCP09781; ZINC38192538; HY-14254A; 3950AH
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| Drug Type |
Small molecular drug
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| Indication | Heart failure [ICD-11: BD10-BD13; ICD-10: I50, I50.9; ICD-9: 428] | Approved | [1], [2] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C14H10N4O
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| Canonical SMILES |
CC1=C(C=C(C(=O)N1)C#N)C2=CN3C=CN=C3C=C2
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| InChI |
1S/C14H10N4O/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10/h2-6,8H,1H3,(H,17,19)
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| InChIKey |
JPAWFIIYTJQOKW-UHFFFAOYSA-N
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| CAS Number |
CAS 106730-54-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4696241, 8152818, 15221182, 26755731, 29216409, 29223682, 50031333, 50783351, 57322339, 90340623, 96024981, 103816637, 104306853, 117512868, 126682944, 128306867, 134340309, 135132659, 137263841, 163620782, 163686107, 164228291, 164814836, 172658312, 174007056, 179149678, 184546129, 184828787, 198984786, 215779060, 223653998, 224893184, 226415186, 242277329, 252480352
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| ChEBI ID |
CHEBI:135019
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 3 (PDE3) | Target Info | Inhibitor | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000438) | |||
| REF 3 | Olprinone: a phosphodiesterase III inhibitor with positive inotropic and vasodilator effects. Cardiovasc Drug Rev. 2002 Fall;20(3):163-74. | |||
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