Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03YVB
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| Former ID |
DIB020005
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| Drug Name |
HG-9-91-01
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| Synonyms |
HY-15776
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C32H37N7O3
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| Canonical SMILES |
CC1=C(C(=CC=C1)C)NC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC=NC(=C3)NC4=CC=C(C=C4)N5CCN(CC5)C
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| InChI |
1S/C32H37N7O3/c1-22-7-6-8-23(2)31(22)36-32(40)39(27-14-13-26(41-4)19-28(27)42-5)30-20-29(33-21-34-30)35-24-9-11-25(12-10-24)38-17-15-37(3)16-18-38/h6-14,19-21H,15-18H2,1-5H3,(H,36,40)(H,33,34,35)
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| InChIKey |
UYUHRKLITDJEHB-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:133818
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Salt-inducible kinase 1 (SIK1) | Target Info | Inhibitor | [1] |
| Salt-inducible kinase 2 (SIK2) | Target Info | Inhibitor | [1] | |
| SIK family kinase 3 (SIK3) | Target Info | Inhibitor | [1] | |
| Pathway Interaction Database | LKB1 signaling events | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. | |||
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