Drug Information
Drug General Information | Top | |||
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Drug ID |
D03RYS
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Former ID |
DIB005531
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Drug Name |
VNA-932
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Synonyms |
WAY-VNA-932; [2-Chloro-4-(3-methyl-1H-pyrazol-1-yl)phenyl](10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10-y-)methanone; 10-[2-Chloro-4-(3-methyl-1H-pyrazol-1-yl)benzoyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine
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Drug Type |
Small molecular drug
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Indication | Urinary incontinence [ICD-11: MF50.2; ICD-9: 788.3] | Discontinued in Phase 1 | [1], [2] | |
Structure |
Download2D MOL |
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Formula |
C23H19ClN4O
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Canonical SMILES |
CC1=NN(C=C1)C2=CC(=C(C=C2)C(=O)N3CC4=CC=CN4CC5=CC=CC=C53)Cl
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InChI |
1S/C23H19ClN4O/c1-16-10-12-28(25-16)18-8-9-20(21(24)13-18)23(29)27-15-19-6-4-11-26(19)14-17-5-2-3-7-22(17)27/h2-13H,14-15H2,1H3
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InChIKey |
JXKQHDZUZGKDGO-UHFFFAOYSA-N
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CAS Number |
CAS 220460-92-4
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Vasopressin V2 receptor (V2R) | Target Info | Agonist | [3], [4] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Vasopressin-regulated water reabsorption | ||||
Pathwhiz Pathway | Vasopressin Regulation of Water Homeostasis | |||
Pathway Interaction Database | Arf6 trafficking events | |||
Reactome | Vasopressin-like receptors | |||
G alpha (s) signalling events | ||||
Vasopressin regulates renal water homeostasis via Aquaporins | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Regulation of Water Balance by Renal Aquaporins | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3537). | |||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013621) | |||
REF 3 | Biased Agonist Pharmacochaperones of the AVP V2 Receptor May Treat Congenital Nephrogenic Diabetes Insipidus. J Am Soc Nephrol. 2009 October; 20(10): 2190-2203. | |||
REF 4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
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