Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03PGC
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| Drug Name |
US8536181, C35
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| Synonyms |
SCHEMBL5240905; CHEMBL3649593; BDBM102337; US8536181, C35
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H22N4O2
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| Canonical SMILES |
C1=CC=C(C=C1)CN2C=CC(=C(C2=O)O)CNCCCN3C=CN=C3
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| InChI |
1S/C19H22N4O2/c24-18-17(13-20-8-4-10-22-12-9-21-15-22)7-11-23(19(18)25)14-16-5-2-1-3-6-16/h1-3,5-7,9,11-12,15,20,24H,4,8,10,13-14H2
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| InChIKey |
VKLSJRDNBKOSAR-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HIF-prolyl hydroxylase 2 (HPH-2) | Target Info | Inhibitor | [1] |
| Target's Patent Info | HIF-prolyl hydroxylase 2 (HPH-2) | Target's Patent Info | [1] | |
| KEGG Pathway | HIF-1 signaling pathway | |||
| Pathways in cancer | ||||
| Renal cell carcinoma | ||||
| Panther Pathway | Hypoxia response via HIF activation | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Prolyl hydroxylase inhibitors. US8536181. | |||
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