Drug Information
Drug General Information | Top | |||
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Drug ID |
D03OLA
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Former ID |
DNC004001
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Drug Name |
L-745631
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Synonyms |
CHEMBL103575; L-745631; SCHEMBL16111943; BDBM50059846
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Drug Type |
Small molecular drug
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Terminated | [1] | |
Structure |
Download2D MOL |
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Formula |
C21H29N3O2S
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Canonical SMILES |
COCCC1CN(CCN1CC(CS)N)C(=O)C2=CC=CC3=CC=CC=C32
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InChI |
1S/C21H29N3O2S/c1-26-12-9-18-14-24(11-10-23(18)13-17(22)15-27)21(25)20-8-4-6-16-5-2-3-7-19(16)20/h2-8,17-18,27H,9-15,22H2,1H3/t17-,18+/m0/s1
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InChIKey |
GKTZPBPAMFCBNI-ZWKOTPCHSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | CAAX farnesyltransferase beta (FNTB) | Target Info | Inhibitor | [2] |
Farnesyl protein transferase (Ftase) | Target Info | Inhibitor | [2] | |
Geranylgeranyl transferase I (GGTase-I) | Target Info | Inhibitor | [2] | |
KEGG Pathway | Terpenoid backbone biosynthesis | |||
Biosynthesis of antibiotics | ||||
NetPath Pathway | TSH Signaling Pathway | |||
Reactome | Inactivation, recovery and regulation of the phototransduction cascade | |||
WikiPathways | Visual phototransduction |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007537) | |||
REF 2 | Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90. |
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