Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03KYG
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| Former ID |
DAP000810
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| Drug Name |
Perindopril
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| Synonyms |
ACEON; Coverex; Coversum; Coversyl; Prestarium; Coverene Cor; Cpd with unspecified MF; Aceon (TN); Acertil (TN); Armix (TN); Coverene (TN); Coverex (TN); Coversum (TN); DW-7950; Prestarium (TN); Prexanil (TN); Prexum (TN); Procaptan (TN); S-9490; SED-9490; McN-A-2833; Perindopril (USAN/INN); Ethyl N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvalinate; (2S)-2-[(1S)-1-Carbethoxybutylamino]-1-oxopropyl-(2S,3aS,7aS)-perhydroindole-2-carboxylic acid; (2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid; (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Approved | [1], [2] | |
| Therapeutic Class |
Antihypertensive Agents
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| Structure |
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Download2D MOL |
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| Formula |
C19H32N2O5
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| Canonical SMILES |
CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O
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| InChI |
1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1
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| InChIKey |
IPVQLZZIHOAWMC-QXKUPLGCSA-N
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| CAS Number |
CAS 82834-16-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9908, 7980282, 10234445, 11364904, 11367466, 11370028, 11372525, 11374329, 11378198, 11484952, 11488924, 11491498, 11492590, 11495762, 12013509, 14755214, 14803882, 17397842, 44436758, 46508767, 48035415, 48259509, 48416399, 50065440, 53787258, 53801152, 56463760, 57338263, 78106573, 85788931, 93166944, 103589744, 104379782, 121363719, 124800274, 126655685, 128203001, 134338091, 134358176, 135047729, 137002499, 143493278, 144206638, 152235952, 152344316, 160964132, 162178238, 163137224, 170464836, 175265414
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| ChEBI ID |
CHEBI:8024
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| ADReCS Drug ID | BADD_D01739 ; BADD_D01740 | |||
| SuperDrug ATC ID |
C09AA04
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| SuperDrug CAS ID |
cas=082834160
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensin-converting enzyme (ACE) | Target Info | Inhibitor | [3] |
| KEGG Pathway | Renin-angiotensin system | |||
| Chagas disease (American trypanosomiasis) | ||||
| Hypertrophic cardiomyopathy (HCM) | ||||
| Pathwhiz Pathway | Angiotensin Metabolism | |||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
| WikiPathways | ACE Inhibitor Pathway | |||
| Metabolism of Angiotensinogen to Angiotensins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6367). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Fixed combination perindopril-amlodipine (Coveram) in the treatment of hypertension and coronary heart disease. Rev Med Liege. 2009 Apr;64(4):223-7. | |||
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