Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03KAY
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| Drug Name |
Darunavir + ritonavir + oseltamivir + hydroxychloroquine
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| Synonyms |
Prezista + norvir + rseltamivir + oxichloroquine
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| Drug Type |
Combination drug
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| Indication | Coronavirus Disease 2019 (COVID-19) [ICD-11: 1D6Y] | Phase 3 | [1] | |
| Therapeutic Class |
Antiviral Agents
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| Structure |
 |
Download2D MOL
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HUMAN glycosylation of host receptor (GHR) | Target Info | Inhibitor | [2], [3] |
| HUMAN pH-dependent viral fusion/replication (pH-DVF/R) | Target Info | Inhibitor | [2], [3] | |
| HUMAN toll-like receptor 7/9 signalling pathway (TLR7/9 pathway) | Target Info | Inhibitor | [4], [5] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04303299) Various Combination of Protease Inhibitors, Oseltamivir, Favipiravir, and Hydroxychloroquine for Treatment of COVID-19 : A Randomized Control Trial | |||
| REF 2 | Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. | |||
| REF 3 | Insights from nanomedicine into chloroquine efficacy against COVID-19. Nat Nanotechnol. 2020 Apr;15(4):247-249. | |||
| REF 4 | Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology. Nat Rev Rheumatol. 2020 Mar;16(3):155-166. | |||
| REF 5 | Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know. Ann Intern Med. 2020 Mar 31. | |||
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