Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03HJK
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| Former ID |
DNC001539
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| Drug Name |
Zithromax
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| Synonyms |
azithromycin; Zithromax; 83905-01-5; Azithromycinum; Azithromycine; Sumamed; Zitromax; Zmax; Hemomycin; Azitrocin; Azasite; Azenil; Aritromicina; Zitrotek; Zithrax; Mixoterin; Setron; Aziwok; Zitrim; Aztrin; Zifin; Tobil; Zmas; Zeto; Azithromycinum [Latin]; Azithromycine [French]; Zithromax IV; AZITHROMYCIN DIHYDRATE; Misultina; Azitromax; Z-Pak; Tromix; Aritromicina [Spanish]; Azitromicina; CP-62993; UNII-J2KLZ20U1M; DRG-0104; CCRIS 1961; HSDB 7205; Azithromycin (anhydrous); C38H72N2O12; BRN 5387583; J2KLZ20U1M; Azythromycin; CHEBI:2955
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Syphilis infection [ICD-11: 1A6Z; ICD-10: A50-A53] | Approved | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C38H72N2O12
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| Canonical SMILES |
CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O
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| InChI |
1S/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
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| InChIKey |
MQTOSJVFKKJCRP-BICOPXKESA-N
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| CAS Number |
CAS 83905-01-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
602741, 826196, 828032, 855291, 7891223, 8150034, 10299997, 11335408, 11360647, 11363201, 11365763, 11368325, 11371605, 11373870, 11376487, 11461619, 11485280, 11489398, 11490469, 11492001, 11494121, 12013987, 14815592, 14913522, 17389173, 24886803, 26612518, 26681126, 37101861, 46507743, 47193725, 47662150, 47885293, 48034991, 48424843, 49648620, 49718186, 49855943, 50085942, 50105431, 53787457, 56312039, 56312690, 56313580, 56320681, 56322740, 56352923, 57404783, 79120868, 81093228
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| ChEBI ID |
CHEBI:2955
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| ADReCS Drug ID | BADD_D00203 ; BADD_D00204 ; BADD_D00205 | |||
| SuperDrug ATC ID |
J01FA10
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| SuperDrug CAS ID |
cas=083905015
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Acidaminococcales | ||||
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Studied Microbe: Phascolarctobacterium
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Phascolarctobacterium was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Actinomycetales | ||||
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Studied Microbe: Actinomyces
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Actinomyces was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Arcanobacterium
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Arcanobacterium was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Aeromonadales | ||||
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Studied Microbe: Succinivibrio
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Succinivibrio was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Alteromonadales | ||||
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Studied Microbe: Shewanella
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Shewanella was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacillales | ||||
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Studied Microbe: Bacillus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Bacillus was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Gemella
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Gemella was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Paenibacillus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Paenibacillus was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Staphylococcaceae
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Staphylococcaceae was increased by Azithromycin (p = 0.031). | |||
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Studied Microbe: Staphylococcaceae
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Staphylococcaceae was increased by Azithromycin (p = 0.031). | |||
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Studied Microbe: Thermicanus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Thermicanus was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides caccae
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Azithromycin (adjusted p-values: 1.39E-05). | |||
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Studied Microbe: Bacteroides fragilis enterotoxigenic
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Azithromycin (adjusted p-values: 5.85E-06). | |||
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Studied Microbe: Bacteroides fragilis nontoxigenic
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis nontoxigenic was decreased by Azithromycin (adjusted p-values: 1.69E-05). | |||
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Studied Microbe: Bacteroides ovatus
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides ovatus was decreased by Azithromycin (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bacteroides thetaiotaomicron
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides thetaiotaomicron was decreased by Azithromycin (adjusted p-values: 9.47E-06). | |||
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Studied Microbe: Bacteroides uniformis
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Azithromycin (adjusted p-values: 6.45E-07). | |||
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Studied Microbe: Bacteroides vulgatus
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Azithromycin (adjusted p-values: 1.97E-06). | |||
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Studied Microbe: Bacteroides xylanisolvens
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides xylanisolvens was decreased by Azithromycin (adjusted p-values: 4.93E-07). | |||
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Studied Microbe: Odoribacter splanchnicus
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Azithromycin (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Parabacteroides distasonis
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Azithromycin (adjusted p-values: 2.74E-07). | |||
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Studied Microbe: Parabacteroides merdae
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Azithromycin (adjusted p-values: 4.93E-07). | |||
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Studied Microbe: Porphyromonas
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Porphyromonas was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Prevotella copri
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Azithromycin (adjusted p-values: 3.34E-04). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Asthma | |||
| Description | The abundance of Bifidobacterium was decreased by Azithromycin (p < 0.05). | |||
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Studied Microbe: Bifidobacterium adolescentis
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium adolescentis was decreased by Azithromycin (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bifidobacterium longum
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium longum was decreased by Azithromycin (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Burkholderiales | ||||
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Studied Microbe: Achromobacter
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Achromobacter was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Advenella
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Advenella was increased by Azithromycin (p = 0.006). | |||
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Studied Microbe: Candidatus Glomeribacter
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Candidatus Glomeribacter was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Mitsuaria
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Mitsuaria was increased by Azithromycin (p = 0.035). | |||
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Studied Microbe: Paucibacter
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Paucibacter was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Schlegelella
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Schlegelella was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Sutterella
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Sutterella was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Campylobacterales | ||||
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Studied Microbe: Campylobacter
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Campylobacter was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Campylobacter
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Campylobacter was increased by Azithromycin (p = 0.007). | |||
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Studied Microbe: Campylobacter upsaliensis
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Campylobacter upsaliensis was decreased by Azithromycin. | |||
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Studied Microbe: Helicobacter
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Helicobacter was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Helicobacteraceae
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Helicobacteraceae was decreased by Azithromycin (p = 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Chroococcales | ||||
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Studied Microbe: Cyanobacterium
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Cyanobacterium was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Collinsella was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Collinsella aerofaciens
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Azithromycin (adjusted p-values: 4.93E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Desulfobacterales | ||||
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Studied Microbe: Desulfosarcina
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Desulfosarcina was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Desulfovibrionales | ||||
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Studied Microbe: Desulfonauticus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Desulfonauticus was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Desulfovibrio
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Desulfovibrio was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eggerthella lenta was decreased by Azithromycin (adjusted p-values: 8.76E-06). | |||
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Studied Microbe: Slackia
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Slackia was increased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Candidatus Blochmannia
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Candidatus Blochmannia was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Enterobacter
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Enterobacter was increased by Azithromycin (p = 0.026). | |||
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Studied Microbe: Enterobacteriaceae
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Enterobacteriaceae was increased by Azithromycin (p = 0.023). | |||
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Studied Microbe: Enterobacteriaceae
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Enterobacteriaceae was increased by Azithromycin (p = 0.023). | |||
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Studied Microbe: Escherichia
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|
[7] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Escherichia was decreased by Azithromycin. | |||
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Studied Microbe: Escherichia coli ED1a
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Escherichia coli ED1a was decreased by Azithromycin (adjusted p-values: 1.00E-05). | |||
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Studied Microbe: Escherichia coli IAI1
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Escherichia coli IAI1 was decreased by Azithromycin (adjusted p-values: 7.20E-07). | |||
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Studied Microbe: Shigella
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Shigella was increased by Azithromycin (p = 0.037). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Bulleidia
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Bulleidia was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Catenibacterium
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Catenibacterium was decreased by Azithromycin (p <= 0.001). | |||
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Studied Microbe: Erysipelatoclostridium ramosum
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Erysipelatoclostridium ramosum was decreased by Azithromycin (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Erysipelotrichaceae
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Erysipelotrichaceae was increased by Azithromycin (p = 0.004). | |||
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Studied Microbe: Turicibacter
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Turicibacter was increased by Azithromycin (p = 0.003). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: alkaliphilus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of alkaliphilus was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Anaerobranca
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Anaerobranca was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Anaerostipes
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Anaerostipes was increased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Blautia
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Blautia was increased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Blautia obeum
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Azithromycin (adjusted p-values: 7.48E-07). | |||
|
Studied Microbe: Caloramator
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Caloramator was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Candidatus Arthromitus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Candidatus Arthromitus was increased by Azithromycin (p = 0.002). | |||
|
Studied Microbe: Clostridium difficile
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|
[7] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Clostridium difficile was not significantly changed by Azithromycin. | |||
|
Studied Microbe: Clostridium perfringens
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Azithromycin (adjusted p-values: 2.40E-06). | |||
|
Studied Microbe: Coprococcus comes
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Azithromycin (adjusted p-values: 3.11E-05). | |||
|
Studied Microbe: Dorea
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Dorea was increased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Dorea formicigenerans
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Azithromycin (adjusted p-values: 5.04E-06). | |||
|
Studied Microbe: Enterocloster bolteae
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Enterocloster bolteae was decreased by Azithromycin (adjusted p-values: 5.63E-06). | |||
|
Studied Microbe: Eubacterium eligens
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium eligens was decreased by Azithromycin (adjusted p-values: 5.58E-06). | |||
|
Studied Microbe: Eubacterium rectale
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Azithromycin (adjusted p-values: 4.04E-04). | |||
|
Studied Microbe: Filifactor
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Filifactor was increased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Heliorestis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Heliorestis was increased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Lacrimispora saccharolytica
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lacrimispora saccharolytica was decreased by Azithromycin (adjusted p-values: 2.73E-07). | |||
|
Studied Microbe: Mogibacterium
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Mogibacterium was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Moryella
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Moryella was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Peptococcus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Peptococcus was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Peptostreptococcus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Peptostreptococcus was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Roseburia hominis
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Azithromycin (adjusted p-values: 1.69E-05). | |||
|
Studied Microbe: Roseburia intestinalis
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Azithromycin (adjusted p-values: 3.43E-04). | |||
|
Studied Microbe: Ruminococcus bromii
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Azithromycin (adjusted p-values: 6.13E-06). | |||
|
Studied Microbe: Ruminococcus gnavus
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Azithromycin (adjusted p-values: 5.04E-06). | |||
|
Studied Microbe: Ruminococcus torques
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Azithromycin (adjusted p-values: 5.51E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Flavobacteriales | ||||
|
Studied Microbe: Polaribacter
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Polaribacter was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Fusobacteriales | ||||
|
Studied Microbe: Fusobacterium
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Fusobacterium was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Geobacterales | ||||
|
Studied Microbe: Geobacter
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Geobacter was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Hyphomicrobiales | ||||
|
Studied Microbe: Agrobacterium
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Agrobacterium was increased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
|
Studied Microbe: Enterococcus
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|
[7] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Enterococcus was not significantly changed by Azithromycin. | |||
|
Studied Microbe: Granulicatella
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Granulicatella was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Lactobacillaceae
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Lactobacillaceae was increased by Azithromycin (p = 0.0016). | |||
|
Studied Microbe: Lactobacillaceae
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Lactobacillaceae was increased by Azithromycin (p = 0.0016). | |||
|
Studied Microbe: Lactobacillus
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Lactobacillus was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Lactobacillus
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Lactobacillus was decreased by Azithromycin (p = 0.002). | |||
|
Studied Microbe: Lactobacillus
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Lactobacillus was decreased by Azithromycin (p = 0.002). | |||
|
Studied Microbe: Lactobacillus paracasei
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lactobacillus paracasei was decreased by Azithromycin (adjusted p-values: 5.04E-06). | |||
|
Studied Microbe: Streptococcaceae
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Streptococcaceae was decreased by Azithromycin. | |||
|
Studied Microbe: Streptococcaceae
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Streptococcaceae was decreased by Azithromycin. | |||
|
Studied Microbe: Streptococcus parasanguinis
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus parasanguinis was decreased by Azithromycin (adjusted p-values: 6.92E-07). | |||
|
Studied Microbe: Streptococcus salivarius
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus salivarius was decreased by Azithromycin (adjusted p-values: 5.51E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Leptospirales | ||||
|
Studied Microbe: Leptospira
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Leptospira was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Micrococcales | ||||
|
Studied Microbe: Rothia
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Rothia was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Pasteurellales | ||||
|
Studied Microbe: Actinobacillus
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Actinobacillus was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Haemophilus
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Haemophilus was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Mannheimia
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Mannheimia was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Rodentia | ||||
|
Studied Microbe: Elusimicrobium
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Elusimicrobium was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Selenomonadales | ||||
|
Studied Microbe: Anaerovibrio
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Anaerovibrio was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Mitsuokella
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Mitsuokella was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Selenomonas
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Selenomonas was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Sphingobacteriales | ||||
|
Studied Microbe: Olivibacter
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Olivibacter was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Sphingobacterium
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Sphingobacterium was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Spirochaetales | ||||
|
Studied Microbe: Borrelia
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Borrelia was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Erysipelothrix
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Erysipelothrix was increased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Thermodesulfovibrionales | ||||
|
Studied Microbe: Thermodesulfovibrio
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Thermodesulfovibrio was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Tissierellales | ||||
|
Studied Microbe: Peptoniphilus
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Peptoniphilus was decreased by Azithromycin (p <= 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Veillonellales | ||||
|
Studied Microbe: Megasphaera
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Megasphaera was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Negativicoccus
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Negativicoccus was decreased by Azithromycin (p <= 0.001). | |||
|
Studied Microbe: Veillonella parvula
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Veillonella parvula was decreased by Azithromycin (adjusted p-values: 5.76E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
|
Studied Microbe: Akkermansia muciniphila
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Akkermansia muciniphila was decreased by Azithromycin (adjusted p-values: 6.54E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Xanthomonadales | ||||
|
Studied Microbe: Stenotrophomonas
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Stenotrophomonas was increased by Azithromycin (p = 0.009). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
|
Studied Microbe: Actinobacteria
Show/Hide Hierarchy
|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Asthma | |||
| Description | The abundance of Actinobacteria was decreased by Azithromycin (p < 0.05). | |||
|
Studied Microbe: Firmicutes
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Firmicutes was decreased by Azithromycin. | |||
|
Studied Microbe: Firmicutes
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Firmicutes was decreased by Azithromycin. | |||
|
Studied Microbe: Proteobacteria
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Proteobacteria was increased by Azithromycin. | |||
|
Studied Microbe: Proteobacteria
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Proteobacteria was increased by Azithromycin. | |||
| Drug Resistance Mutation (DRM) | Top | |||
|---|---|---|---|---|
| DRM | DRM Info | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial 50S ribosomal RNA (Bact 50S rRNA) | Target Info | Modulator | [8] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
| REF 2 | Gut Microbial Diversity in Antibiotic-Naive Children After Systemic Antibiotic Exposure: A Randomized Controlled Trial. Clin Infect Dis. 2017 May 1;64(9):1147-1153. | |||
| REF 3 | Metagenomic Analysis of Antibiotic-Induced Changes in Gut Microbiota in a Pregnant Rat Model. Front Pharmacol. 2016 Apr 28;7:104. | |||
| REF 4 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 5 | Short- and long-term impacts of azithromycin treatment on the gut microbiota in children: A double-blind, randomized, placebo-controlled trial. EBioMedicine. 2018 Dec;38:265-272. | |||
| REF 6 | Gut microbiome alteration in MORDOR I: a community-randomized trial of mass azithromycin distribution. Nat Med. 2019 Sep;25(9):1370-1376. | |||
| REF 7 | Double-blind, placebo-controlled study comparing the effect of azithromycin with clarithromycin on oropharyngeal and bowel microflora in volunteers. Eur J Clin Microbiol Infect Dis. 2002 Jun;21(6):427-31. | |||
| REF 8 | The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. | |||
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