Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D03FLC
|
|||
Former ID |
DAP000039
|
|||
Drug Name |
Lamotrigine
|
|||
Synonyms |
Crisomet; Labileno; Lamictal; Lamictin; Lamiktal; Lamitor; Lamotrigina; Lamotriginum; Desitin Brand of Lamotrigine; Faes Brand of Lamotrigine; Glaxo Wellcome Brand of Lamotrigine; GlaxoSmithKline Brand of Lamotrigine; Juste Brand of Lamotrigine; Lamictal Cd; Lamictal ODT; Lamictal XR; Lamotrigina [Spanish]; Lamotriginum [Latin]; BW 430C; GI 267119X; GW 273293; L 3791; BW-430C; EUR-1048; Lamictal (TN); Lamictin (TN); Lamotrigine [USAN:INN:BAN]; Lamotrigine (JAN/USAN/INN); 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine; 3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine; 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine; 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine; 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diyldiamine; 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Bipolar disorder [ICD-11: 6A60; ICD-10: F31] | Approved | [1], [2] | |
Epilepsy [ICD-11: 8A60-8A68] | Approved | [1], [2] | ||
Therapeutic Class |
Anticonvulsants
|
|||
Company |
GSK
|
|||
Structure |
Download2D MOL |
|||
Formula |
C9H7Cl2N5
|
|||
Canonical SMILES |
C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N
|
|||
InChI |
1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
|
|||
InChIKey |
PYZRQGJRPPTADH-UHFFFAOYSA-N
|
|||
CAS Number |
CAS 84057-84-1
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
855818, 5669156, 7847420, 7979720, 8152444, 11111377, 11113342, 11528749, 12013463, 14823602, 17405249, 24278792, 26719658, 29222992, 46386680, 46505408, 47810853, 48259345, 48416154, 50100261, 50104089, 50104090, 53777794, 53787568, 56423136, 57322032, 58107296, 76843584, 81092819, 85231112, 90341162, 91148150, 92304062, 92308151, 92308280, 92308924, 92709766, 93166952, 103199382, 103940000, 104179107, 104304778, 111978157, 117872151, 121361621, 124658861, 124799528, 124880544, 124880545, 124880546
|
|||
ChEBI ID |
CHEBI:6367
|
|||
ADReCS Drug ID | BADD_D01243 | |||
SuperDrug ATC ID |
N03AX09
|
|||
SuperDrug CAS ID |
cas=084057841
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Voltage-gated sodium channel alpha Nav1.9 (SCN11A) | Target Info | Blocker | [3] |
Reactome | Interaction between L1 and Ankyrins |
References | Top | |||
---|---|---|---|---|
REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2622). | |||
REF 2 | Use of second-generation antiepileptic drugs in the pediatric population. Paediatr Drugs. 2008;10(4):217-54. | |||
REF 3 | The effects of lamotrigine on the acquisition and expression of morphine-induced place preference in mice. Pak J Biol Sci. 2009 Jan 1;12(1):33-9. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.