Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03EZB
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| Former ID |
DIB014586
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| Drug Name |
AR-H047108
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| Synonyms |
RAPID, AstraZeneca; Reversible acid pump inhibitor, AstraZeneca
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| Indication | Duodenal ulcer [ICD-11: DA63] | Discontinued in Phase 2 | [1] | |
| Company |
AstraZeneca plc
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H24N4O
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| Canonical SMILES |
CCC1=CC=CC(=C1CNC2=CC(=CN3C2=NC(=C3C)C)C(=O)N)C
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| InChI |
1S/C20H24N4O/c1-5-15-8-6-7-12(2)17(15)10-22-18-9-16(19(21)25)11-24-14(4)13(3)23-20(18)24/h6-9,11,22H,5,10H2,1-4H3,(H2,21,25)
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| InChIKey |
IDSZXCFCCNVXER-UHFFFAOYSA-N
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| CAS Number |
CAS 248281-68-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gastric H(+)/K(+) ATPase (Proton pump) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013302) | |||
| REF 2 | Early stellate cell activation and veno-occlusive-disease (VOD)-like hepatotoxicity in dogs treated with AR-H047108, an imidazopyridine proton pump inhibitor.Toxicol Pathol.2008 Jul;36(5):727-37. | |||
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