Drug Information
Drug General Information | Top | |||
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Drug ID |
D03DMB
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Former ID |
DNCL003622
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Drug Name |
Tapinarof
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Synonyms |
GSK-2894512; GSK2894512
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Indication | Plaque psoriasis [ICD-11: EA90.0; ICD-10: L40.0; ICD-9: 696] | Approved | [1] | |
Atopic dermatitis [ICD-11: EA80; ICD-10: L20; ICD-9: 691.8, 692.9] | Phase 2 | [2] | ||
Psoriasis vulgaris [ICD-11: EA90; ICD-9: 696] | Phase 2 | [3] | ||
Company |
Dermavant
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Structure |
Download2D MOL |
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Formula |
C17H18O2
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Canonical SMILES |
CC(C)C1=C(C=C(C=C1O)C=CC2=CC=CC=C2)O
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InChI |
1S/C17H18O2/c1-12(2)17-15(18)10-14(11-16(17)19)9-8-13-6-4-3-5-7-13/h3-12,18-19H,1-2H3/b9-8+
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InChIKey |
ZISJNXNHJRQYJO-CMDGGOBGSA-N
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CAS Number |
CAS 79338-84-4
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Aryl hydrocarbon receptor (AHR) | Target Info | Agonist | [1] |
References | Top | |||
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REF 1 | FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 215272. | |||
REF 2 | ClinicalTrials.gov (NCT02564042) A Dose-Finding Study of GSK2894512 Cream in Subjects With Plaque Psoriasis. | |||
REF 3 | ClinicalTrials.gov (NCT01098734) Non-steroid, Atopic Dermatitis Phase IIb 12-week Trial; Topical WBI-1001 Cream. U.S. National Institutes of Health. |
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