Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03CFJ
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| Former ID |
DIB002709
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| Drug Name |
NCX-701
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| Synonyms |
Nitroparacetamol; NO-acetaminophen, NicOx; NO-paracetamol, NicOx
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD-11: MG30-MG3Z] | Discontinued in Phase 2 | [1] | |
| Company |
NicOx SA
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| Structure |
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Download2D MOL |
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| Formula |
C12H14N2O6
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| Canonical SMILES |
CC(=O)NC1=CC=C(C=C1)OC(=O)CCCO[N+](=O)[O-]
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| InChI |
1S/C12H14N2O6/c1-9(15)13-10-4-6-11(7-5-10)20-12(16)3-2-8-19-14(17)18/h4-7H,2-3,8H2,1H3,(H,13,15)
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| InChIKey |
XTMOQAKCOFLCRZ-UHFFFAOYSA-N
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| CAS Number |
CAS 326850-30-0
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prostaglandin G/H synthase (COX) | Target Info | Modulator | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014096) | |||
| REF 2 | Antinociceptive effects of NCX-701 (nitro-paracetamol) in neuropathic rats: enhancement of antinociception by co-administration with gabapentin. Br J Pharmacol. 2009 September; 158(2): 601-609. | |||
| REF 3 | Nitroparacetamol (NCX-701) and pain: first in a series of novel analgesics. CNS Drug Rev. 2007 Fall;13(3):279-95. | |||
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