Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03BGG
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| Former ID |
DIB015691
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| Drug Name |
ST-1141
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| Synonyms |
Ghrelin agonist (oral, opioid-induced bowel dysfunction), Helsinn
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| Indication | Functional bowel disorder [ICD-11: DD91; ICD-10: K00-K93] | Phase 1 | [1] | |
| Company |
Sapphire Therapeutics Inc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Growth hormone secretagogue receptor 1 (GHSR) | Target Info | Agonist | [2] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | Leptin Signaling Pathway | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025998) | |||
| REF 2 | The Prokinetic Face of Ghrelin. International Journal of Peptides Volume 2010 (2010), Article ID 493614, Page(11). | |||
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