Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02YOO
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| Former ID |
DNC008662
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| Drug Name |
NISOXETINE
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| Synonyms |
Nisoxetine; 3-(2-Methoxyphenoxy)-N-methyl-3-phenylpropylamine; Compound 89218; 3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine; Nisoxetine [USAN:INN]; 3-(o-Methoxyphenoxy)-N-methyl-3-phenylpropylamine; N-Methyl-gamma-(2-methylphenoxy)phenylpropanolamine; Lilly 94939; 57226-61-6; DL-N-Methyl-3-(o-methoxyphenoxy)-N-methyl-3-phenylpropylamine; CHEMBL295467; 53179-07-0; CHEBI:73410; ITJNARMNRKSWTA-UHFFFAOYSA-N; 57754-86-6; NCGC00015715-04; Nisoxetine Inhibitor; DSSTox_RID_80724; DSSTox_CID_25175; DSSTox_GSID_45175
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H21NO2
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| Canonical SMILES |
CNCCC(C1=CC=CC=C1)OC2=CC=CC=C2OC
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| InChI |
1S/C17H21NO2/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2/h3-11,15,18H,12-13H2,1-2H3
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| InChIKey |
ITJNARMNRKSWTA-UHFFFAOYSA-N
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| CAS Number |
CAS 53179-07-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
143845, 3249458, 5054385, 7980130, 8152773, 11466938, 11468058, 11486695, 14799314, 26752034, 29223594, 47206897, 47217006, 47365427, 47365428, 47515548, 47515549, 48035363, 48110689, 49699321, 49846232, 50064869, 50104694, 50647659, 57322302, 85753306, 85787336, 90341689, 92308889, 99381446, 103123188, 103224657, 104171195, 104306586, 117535777, 124750083, 124880820, 124880821, 126407913, 128217697, 134345867, 135003536, 135143164, 137016425, 142365343, 144203754, 162875691, 163425846, 170466483, 176483984
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| ChEBI ID |
CHEBI:73410
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4637). | |||
| REF 2 | Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI). Bioorg Med Chem Lett. 2008 Jul 15;18(14):4224-7. | |||
| REF 3 | Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4929-31. | |||
| REF 4 | 1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors. Bioorg Med Chem Lett. 2009 Jan 1;19(1):58-61. | |||
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