Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02UCT
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| Former ID |
DNC001192
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| Drug Name |
R-820
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C30H30N4O4
|
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| Canonical SMILES |
CN(CC1=CC=CC=C1)C(=O)C(C2=CC=CC=C2)NC(=O)C3CC(CN3C(=O)C4=CNC5=CC=CC=C54)O
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| InChI |
1S/C30H30N4O4/c1-33(18-20-10-4-2-5-11-20)30(38)27(21-12-6-3-7-13-21)32-28(36)26-16-22(35)19-34(26)29(37)24-17-31-25-15-9-8-14-23(24)25/h2-15,17,22,26-27,31,35H,16,18-19H2,1H3,(H,32,36)/t22-,26+,27+/m1/s1
|
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| InChIKey |
JSNQZGVYABLKPW-ICTDUYRTSA-N
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuromedin-K receptor (TACR3) | Target Info | Antagonist | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Reactome | G alpha (q) signalling events | |||
| WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Implication of nigral tachykinin NK3 receptors in the maintenance of hypertension in spontaneously hypertensive rats: a pharmacologic and autoradiographic study. Br J Pharmacol. 2003 Feb;138(4):554-63. | |||
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