Drug Information
Drug General Information | Top | |||
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Drug ID |
D02TMO
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Former ID |
DIB007959
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Drug Name |
177Lu-AMBA
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Synonyms |
Ga67-AMBA; Ga68-AMBA; Galenium67-AMBA; Galenium68-AMBA; In111-AMBA; Indium-111-AMBA; Lutetium-111-AMBA; Gastrin releasing peptide receptor agonist (radiotherapeutic, cancer), Bracco; GRP-R agonist (radiotherapeutic, cancer), Bracco; 111In-AMBA; 177Lu-AMBA (cancer), Marillion Pharmaceuticals; 177Lu-DOTA-G-4-aminobenzoyl-QWAVGHLM-NH2; 67Ga-AMBA; 68Ga-AMBA
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Indication | Breast cancer [ICD-11: 2C60-2C65] | Phase 1 | [1] | |
Company |
Bracco SpA
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Structure |
Download2D MOL |
Target and Pathway | Top | |||
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Target(s) | Gastrin-releasing peptide receptor (GRPR) | Target Info | Agonist | [2] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Reactome | Peptide ligand-binding receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Peptide GPCRs | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029232) | |||
REF 2 | Multimodality imaging and preclinical evaluation of 177Lu-AMBA for human prostate tumours in a murine model. Anticancer Res. 2010 Oct;30(10):4039-48. |
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